Case Report Published on 14 Mar, 2024

Mammary Angiosarcoma in an Adolescent : A Case Report

Mammary Angiosarcoma in an Adolescent
Vol. 19 No. 1 : 2024 (315-323)

teh sx teh sx
norlia a norlia a
NORDASHIMA AS NORDASHIMA AS
elia shazniza s elia shazniza s
marfuah ne marfuah ne
Shahizon Azura MM Shahizon Azura MM

Abstract
Mammary angiosarcoma is an extremely rare and highly aggressive malignant tumour of vascular origin. It can be divided into 2 types; primary angiosarcoma which develops de-novo and secondary angiosarcoma which occurs as a complication of post-radiotherapy or chronic lymphoedema. We present a case of a 19-year-old adolescent with a large right breast mass for the duration of 9 months. The core biopsy was reported as an angiosarcoma. She did not have any previous breast pathology. She underwent a right mastectomy, followed by adjuvant radiotherapy. She developed scalp and skull metastases 5 months post-surgery and was currently undergoing palliative chemotherapy. There is a lack of international consensus on the management of mammary angiosarcoma due to its rarity. The main modality of management is surgery, preferably mastectomy. Radiotherapy and chemotherapy are sometimes given in an attempt to prevent or treat local recurrence and metastasis.
Keywords : Adolescent, mammary angiosarcoma, mastectomy, skull metastases,
Abstrak
Angiosarkoma payudara adalah tumor malignan yang jarang dijumpai dan sangat agresif yang berpunca dari salur darah. Ia terbahagi kepada 2 jenis; angiosarkoma primer yang terbentuk dengan sendirinya dan angiosarkoma sekunder yang terhasil akibat komplikasi selepas radioterapi atau limfedema kronik. Kami membentangkan kes seorang gadis yang berumur 19 tahun, telah hadir dengan ketulan yang besar di payudara kanannya untuk tempoh 9 bulan. Biopsi teras ketulan itu dilaporkan sebagai angiosarkoma. Dia tidak mempunyai sebarang penyakit di bahagian payudara sebelum ini. Dia telah menjalani mastektomi kanan, diikuti dengan radioterapi adjuvan. Dia telah dikesan mengalami tumor itu yang telah merebak ke kulit kepala dan tengkoraknya 5 bulan selepas pembedahan dan dia sedang menjalani kemoterapi paliatif. Tidak terdapat garis panduan antarabangsa yang jelas berkaitan rawatan angiosarkoma payudara disebabkan penyakit ini jarang dijumpai. Rawatan utama adalah pembedahan, di mana mastektomi adalah disyorkan. Radioterapi dan kemoterapi kadangkala diberikan dalam usaha untuk mengelak atau merawat penyakit yang berulang atau yang telah  merebak.
Kata Kunci : Angiosarkoma payudara, mastektomi, merebak ke tengkorak, remaja,

Correspondance Address
Professor Dr. Norlia Abdullah. Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +603-9145 5795 Email: norlia@ppukm.ukm.edu.my Abbad, F., Idrissi, N.C., Fatih, B., Fakhir, B., Drissi, J., Khouchani, M., Rais, H. 2017. Primary breast angiosarcoma: A rare presentation of rare tumor - Case report. BMC Clin Pathol 17: 17. Alexandrova, E., Sergieva, S., Mihaylova, I., Zarkova, A. 2014. Primary angiosarcoma of the breast complicated by the syndrome of disseminated intravascular coagulation (DIC): Case report and literature review. Rep Pract Oncol Radiother 19(3): 221-5.

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